I swear I will put you back together even if it means breaking myself." -Twilight sparkle Language: English Words: 17,477 Chapters: 14/? Comments: 1 Kudos: 9 Hits: 278 "When this war is over, we will return to our homes and feel that we can't ask for no higher honor. Big Macintosh (My Little Pony: Friendship is Magic).Trixie Lulamoon (My Little Pony: Friendship is Magic).Princess Luna (My Little Pony: Friendship is Magic).Princess Celestia (My Little Pony: Friendship is Magic).King Sombra (My Little Pony: Friendship is Magic).Discord (My Little Pony: Friendship is Magic).Discord/Fluttershy (My Little Pony: Friendship is Magic).Applejack/Rarity (My Little Pony: Friendship is Magic).Starlight Glimmer/Trixie Lulamoon (My Little Pony: Friendship is Magic).Graphic Depictions Of Violence, Major Character Death.One shots of ships featuring Twilight Sparkle Language: English Words: 355 Chapters: 1/5 Kudos: 2 Bookmarks: 1 Hits: 23 Rainbow Dash (My Little Pony: Friendship is Magic).Fluttershy (My Little Pony: Friendship is Magic).Applejack (My Little Pony: Friendship is Magic).Rarity (My Little Pony: Friendship is Magic).
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This is a massive scene generator bundle that comes with more than 320 different elements in transparent PNG file format. Even beginning designers can easily edit the PSD files using Photoshop to create stylish mockup scenes to present their designs to clients or showcase them on portfolio websites. The best part is they are very easy to edit and customize. These scene generators often include more than 100 isolated items in PNG and PSD format and come in all kinds of categories for showcasing different types of designs, including website designs, app designs, stationery designs, logo designs, and much more. What Is A Mockup Generator?Ī mockup or a scene generator is a bundle of graphics and elements that allows you to create your own unique scenes for showcasing and presenting your designs.įor example, there are mockup generator bundles that include dozens of separated images of items such as tables, laptops, books, lamps, and other decorative elements you can move and rearrange however you like to create a scene to promote your designs. The best part is that you’ll be able to use these scene generators to create all the images you need for various projects. Scene and mockup generators are bundles of elements and objects, which you can use to create your own unique header images, product mockup scenes, and custom graphics however you like. However, there’s a simpler solution to this problem: Scene generators! Even when you do find a great image, you later discover that someone else is using that exact same image on a different website. Mostly because high-quality stock photos and images are hard to find, and can come with hefty price tags. Using a mockup generator can help you tweak and customize a mockup to match your needs perfectly. It isn’t always easy to find the right mockup for your header or feature image. I will know that you lack self-discipline. I will change your memorandum and make it right. If you start chatting about the case before you have covered items 1, 2, and 3, I will notice your error.
Thus, it is imperative to explore more effective treatment strategies to improve the prognosis of neonatal hypoxic-ischemic (HI) brain damage. The treatment effects of hypothermia on moderate or severe patients are very limited, and even have many adverse reactions ( Michniewicz et al., 2022). Despite the application of hypothermia as the reliable standard therapy for neonatal HIE, the treatment time window of hypothermia is very narrow ( Sahuquillo and Vilalta, 2007 Goswami et al., 2020). HIE is not a single occurrence, but is an ongoing process that leads to neuronal death within hours to days after the initial injury ( Jaworska et al., 2017). The nearly half of HIE patients die in the neonatal period, and surviving infants have a high risk of neurological sequelae, which can cause global public health burden ( Rocha-Ferreira and Hristova, 2015). Perinatal asphyxia-induced hypoxic-ischemic encephalopathy (HIE) is one of the important causes of neonatal death and nervous system dysfunction ( Sun et al., 2017). In addition, the NRF2 inhibitor M元85 could significantly reverse the effects of myricetin.Ĭonclusion: This study found that myricetin might alleviate oxidative stress and apoptosis through NRF2 signaling pathway to exert the protective role for HI injury, which suggested that myricetin might be a promising therapeutic agent for HIE. Results: Our results showed that myricetin intervention could significantly reduce brain infarction volume, glia activation, apoptosis, and oxidative stress marker levels through activating NRF2 (Nuclear factor-E2-related factor 2) and increase the expressions of NRF2 downstream proteins NQO-1 and HO-1. Methods: In this study, we established the neonatal rats hypoxic-ischemic (HI) brain damage model in vivo and CoCl 2 induced PC1 2 cell model in vitro to explore the neuroprotective effects of myricetin on HI injury, and illuminate the potential mechanism. However, the role and underlying molecular mechanism of myricetin on HIE remain unclear. Myricetin, a naturally extracted flavonol compound, exerts remarkable effects against oxidative stress, apoptosis, and inflammation. Both oxidative stress and apoptosis play critical roles in the pathological development of HIE. Introduction: Hypoxic-ischemic encephalopathy (HIE) is a crucial cause of neonatal death and neurological sequelae, but currently there is no effective therapy drug for HIE.
An informed and actively engaged public plays a vital role in helping each station to operate appropriately in serving the needs of its local community. If you have any concerns about a local station – including its general operation, programming or other matters – make your opinion known to the licensee and, if necessary, advise us of your concerns so we can look into the matter. The public file is an excellent resource to gauge a station’s performance of its obligations as a Commission licensee.Īdditionally, the purpose of this Manual is to provide you with the basic tools necessary to ensure that the stations licensed to serve you meet their obligations and provide high quality broadcast service. Each commercial and noncommercial station also must maintain a public inspection file on the FCC’s website that contains these reports, as well as other materials pertaining to the station’s operations and dealings with the FCC and with the community it is licensed to serve. The report contains a listing of the programming the station aired that the licensee believes provided significant treatment of issues facing the community. As discussed in more detail further in this Manual, each commercial station – and most noncommercial stations – must provide the public with information about how it has met its obligation in a quarterly report. To do this, each non-exempt station licensee must identify the needs and problems and then specifically treat these local matters in the news, public affairs, political and other programming that it airs. In exchange for obtaining a valuable license to operate a broadcast station using the public airwaves, each radio and television licensee is required by law to operate its station in the “public interest, convenience and necessity.” Generally, this means it must air programming that is responsive to the needs and problems of its local community of license. It provides a brief overview of the regulation of broadcast radio and television licensees, describing how the FCC authorizes broadcast stations, the various rules relating to broadcast programming and operations that stations must comply with, and the essential obligation of licensees that their stations serve their local communities. This Manual is published by the Federal Communications Commission (FCC), the federal agency directed by Congress to regulate broadcasting. Information on Third-Party Fundraising by NCE stations Sponsorship Identification - Political Matter and Controversial Issues of Public Importance Must-Carry or Retransmission Consent ElectionsĬlass A TV Continuing Eligibility Documentation Records Concerning Children's Programming Commercial Limits Material Relating to an FCC Investigation or Complaintĭonor Lists for Non-Commercial Educational Channels ("NCEs") Requirement to Maintain a Public Inspection FileĬhildren's Television Programming Reports How to Resolve Blanketing Interference Problems Underwriting Announcements on Noncommercial Educational Stations How to File an Obscenity, Indecency, or Profanity ComplaintĮducational and Informational ProgrammingĪccess to Broadcast Material by People with DisabilitiesĪpparatus Requirements for Emergency Information and Video Descriptionīusiness Practices, Advertising Rates, and ProfitsĮmployment Discrimination and Equal Employment Opportunity ("EEO") Obscene, Indecent, or Profane Programming Programming Inciting "Imminent Lawless Action" Political Broadcasting: Candidates for Public Office Public Participation in the Licensing Processīroadcast Programming: Basic Law and PolicyĬriticism, Ridicule, and Humor Concerning Individuals, Groups, and Institutionsīroadcast Programming: Law and Policy on Specific Kinds of Programming Revised September 2021 A PDF version of this document is available HERE.įCC Regulation of Broadcast Radio and TelevisionĬommercial and Noncommercial Educational StationsĪpplications to Build New Stations Length of License Period Chu ( Crazy Rich Asians)Ĭast: Anthony Ramos, Corey Hawkins. Where to watch it: Rent on Amazon, iTunes, Vudu, and YouTube ( Watch the trailer) Warner Brosĭirector: Jon M. Mostly, you leave feeling a towering affection for these weirdos and their weirdo music, which is, I assume, exactly what Wright intended. (Wright has a great time with the chyrons identifying these talking heads.) There are animated recreations, recreations acted out by the elder Maels, and tons of archival footage. It's meticulous and also enormously funny, featuring insight from the Maels themselves as well as devoted fans like Flea, Weird Al, and Mike Myers. The director methodically goes through the Maels' discography, highlighting their pop experiments and deeply amusing and bizarre lyrics. Wright sets out to explain the underground phenomenon behind Sparks, which has weaved in and out of the public eye since the early 1970s. Why it's great: I knew practically nothing about the band Sparks, made up of the brothers Russ and Ron Mael, going into Edgar Wright's loving and long documentary, but I emerged a fan, which is some of the highest praise I can give a film like this one. Where to watch: Rent on Amazon, iTunes, Vudu, and YouTube ( Watch the trailer) But, with Lin throwing everything he's got at the screen, F9 delivers the goods when it comes to the huge set-pieces, particularly any time a magnet is involved, and Diesel, rumbling with each line reading, remains a fascinating screen presence in these films, which still feel personal to him despite their ridiculous scale and unapologetic cheesiness. The plot is mostly nonsense John Cena is not a particularly compelling villain the "comedy" bits stop the movie in its tracks. If you find these proudly melodramatic, unrepentantly goofy movies tedious, F9 will not be the one to win you over. He's clearly doing some necessary tune-up work here, stripping the series for parts (say goodbye to The Rock!) and futzing with the engine (say hello to some surprisingly compelling flashbacks to Dom's teenage years!). Why it’s great: After the bloated Fate of the Furious, which found the Fast franchise careening off the icy cliff of self-parody and into the freezing waters of self-indulgence, F9 serves as a necessary course correction courtesy of filmmaker Justin Lin, who helmed the best entry in the series with Fast Five and saved it from direct-to-DVD purgatory with Tokyo Drift. Cast: Vin Diesel, Michelle Rodriguez, Tyrese Gibson, Chris "Ludacris" Bridgesĭirector: Justin Lin ( Fast and Furious 6) Samples, without any further purification, were analyzed by SDS-PAGE (both 8% and 16% gels) with Coomassie staining. After each stage, sample was eluted from one aliquot of resin with biotin (lanes 4 -13). Catcher led to chain formation up to a decamer. Catcher was bound to monomeric avidin resin. leak user identity and even potentially snoop on your traffic. (b) Solid-phase polyprotein synthesis using avidin attachment. The above diagram comes from the paper Easy 4G/LTE IMSI Catchers for Non-Programmers. The bound sugar part is shown in space-fill and colored magenta. Shawna Wright (1) Catcher - Photo GalleryWashington 2013 (Senior): Drew a walk in game one vs. Mutated residues are shown in space-fill. A 312 was changed to V, I 317 to V, and 172 -173 and 175 -176 were deleted. (a) Location of MBP mutations, based on PDB 1 ANF. Her power at the plate will be noticed immediately as we will see a lot of balls land in the lake off her. Shawna can catch and play the infield corner positions. Resin attachment for solid-phase polyprotein synthesis. 'Ever since we've known Shawna Wright, we've wanted her to be a part of Husky softball. Tag-MBP are shown alone or mixed for the indicated times (triplicate samples), before SDS-PAGE with Coomassie staining.Ī MBP A 312 I 317 172 -173 175 -176 Bound sugar - + - 1 1 2 2 3 3 4 4 Spy. Saalbach hinterglemm leogang wikipedia, Ash catcher gravity bong. (c) Sample gel to test for quantitative reaction of Snoop. Statika u prostoru zadaci, Ibbankatuwa wewa dambulla, Pembukaan cpns jakarta 2013. Catcher are shown alone or mixed for 32 min (triplicate samples), before SDS-PAGE with Coomassie staining. (b) Sample gel to test for quantitative reaction of Snoop. It takes a snapshot using the built-in webcam of whatever is in front of it whenever the computer is woken up. The Lys, Asn and Glu involved in isopeptide bond formation are shown in stick-format in yellow and the rest of Snoop. A in cartoon format (based on PDB 2 WW 8), residues mutated are shown in space-fill with carbons in cyan (G 842 was changed to T and D 848 to G). Tag-MBP Reactive triad c Time (min) Tag Catcher 0 0 Tag and Catcher (4: 1) 32 64 128 Snoop. A HisTag and GSG linker was added to the N-terminus of the protein beta prefoldin. Tag b Tag 0 G 842 Tag and Catcher (1: 2) 0 32 min Snoop. Snoop Catcher is currently free (was 9.99). In the same year, the actress was nominated for Best British Newcomer at the BFI London Film Festival as well as for Young British / Irish Performer of the Year by the London Film Critics' Circle. Tara Brady of The Irish Times deemed Pugh "remarkable", while IndieWire's Oliver Lyttelton called her "striking". While still studying in sixth form, Pugh made her professional acting debut in the 2014 drama The Falling, playing a precocious teenager opposite Maisie Williams. Pugh at the 2014 BFI London Film Festival She was privately educated at Wychwood School and St Edward's School, Oxford, but disliked how the schools did not support her acting ambitions. Also at six years old, Pugh played Mary in a school nativity play, for which she spoke in a Yorkshire accent. They lived there until she was six, when they moved back to Oxford. The family relocated to Sotogrande in Spain when Pugh was three years old, hoping the warmer weather would improve her health. She suffered from tracheomalacia as a child, which led to frequent hospitalisations. She has three siblings: actor and musician Toby Sebastian, actress Arabella Gibbins, and Rafaela "Raffie" Pugh. She has since starred in the thriller Don't Worry Darling and the drama The Wonder (both 2022).įlorence Pugh was born on 3 January 1996 in Oxford to dancer Deborah and restaurateur Clinton Pugh. In 2021, she starred as Yelena Belova in the Marvel Cinematic Universe superhero film Black Widow and the Disney+ miniseries Hawkeye. Pugh was awarded the Trophée Chopard at the 2019 Cannes Film Festival. For the last of these, she received nominations for an Academy Award and a BAFTA Award. Pugh's international breakthrough came in 2019 with her portrayals of professional wrestler Paige in the biographical sports film Fighting with My Family, a despondent American woman in the horror film Midsommar, and Amy March in the period drama Little Women. After starring in the 2018 television film King Lear, she drew praise for her leading role in the miniseries The Little Drummer Girl and earned a nomination for the BAFTA Rising Star Award that year. Pugh gained recognition in 2016 for her leading role as a young bride in the independent drama Lady Macbeth, winning a British Independent Film Award. She made her acting debut in 2014 in the drama film The Falling. Florence Pugh ( / p j uː/ PEW born 3 January 1996) is an English actress. Wine and beer and some snacks are available as well. Everything is supplied including aprons, brushes, canvas, etc. The hot tasty bites, cold shareable plates, and luxe desserts are perfect for snacking in one hand while you keep on keepin’ on with your brush in the other. It's a casual art studio where you sit in groups of six or so and follow the instructions to paint your own masterpiece. There are no starving artists around here, either! By design the menu caters to those who strive to have a brush in one hand and a boneless wing in the other. They also have a variety of sodas, juices, and non alcoholic options available. Muse has a fully stocked beer & wine bar – and the house made boozy punch is the true definition of liquid inspiration. You won’t need to BYO…anything to help you get those creative juices flowing. 25 for admission for one to a Paint Nite Drinkware Event (45 value) 49 for two Groupons, each valid for admission for one to a Paint Nite Drinkware Event (90 value) 99 for four Groupons, each valid for admission for one to a Paint Nite Drinkware Event (180 value) Being social shouldn’t involve a screen. You won’t find more options, or variety of paint styles out there and with (literally) thousands of paintings to choose from there’s definitely a painting that will be perfect for your whole crew. They also host private parties if you’re looking for something a little more VIP. MUSE PAINTBAR PHONE (888) 607-6873 HOURS See Class Schedule LOCATION 217 Patriot Place Foxborough, MA 02035 View Directory Map LINKS Looking for a different night out Try Muse Paintbar A perfect girls’ night out, birthday, bachelorette party, first date, or forty-first date. Each month you pick from a curated event calendar filled with classic favorites, fun theme nights, and brand new seasonal paintings to choose from. A great option for date night, girls’ night, a birthday or bachelorette party, or a team building event…and absolutely NO art experience is required! They’ll show you step-by-step how to paint from mixing colors, to how to hold your brush, if there’s a trick for it they’ll show you how it’s done. The Gulf of Corryvreckan is a narrow strait between the islands of Jura and Scarba on the west coast of Scotland. The rest of Jura can be explored fairly easily if you take a car on the ferry but note that the roads are single-track with few passing places and not too many safe spots to park due to the vast swathes of spongy blanket bog that covers the majority of the island.Ģ: Corryvreckan whirlpool. I wasn’t lying when I said that part of the island is remote! Orwell was so taken with the remoteness of this part of the island that he wrote 1984 while staying there, so if you’re a fan of the author you might consider making a booking – though you’ll be relying on a generator for electricity and a coal-fired heater for hot water. This house was a favourite retreat for George Orwell and it’s so remote you’ll need a 4×4 to get there. Check out the Jura Hotel website for availability.Īnother recommended place to stay (but not by me as it currently costs £1000 a week!) is Barnhill farmhouse located on the far north of the island. I wholeheartedly recommend you consider the hotel for at least one night, especially considering the prices are reasonable as well. The rooms are a bit basic by modern city standards but they’re clean and comfortable and the food in the restaurant is excellent. One option for an overnight stay is to book a room at the Jura hotel next door which features fantastic views overlooking the harbour where you’ll be treated to an almost untouched landscape of sandy bays and deep-blue water, guaranteeing a memorable evening watching the sunset with a fine whisky in hand. Instead, go to the Jura distillery website and fill in your details 24 hours beforehand to reserve your space, and remember there’s a good chance you’ll get a sample or two during your visit so you won’t be able to drive afterwards. You can join a distillery tour when you visit (around £10 per person) which is well worth taking the time for, but note that booking is essential so don’t get there and expect to immediately join the tour. I tried a few samples during my visit and I can totally recommend both ‘Origin’ (honey finish) and ‘Prophecy’ (peat finish) if you’re after a decent dram or three. Isle of Jura whisky ranges in flavours from non-peated to heavily peated so it manages to bridge the gap between the sweet floral notes of mainland whisky and the often medicinal whisky produced on Islay. When I first arrived at the tiny Feolin ferry terminal I wasn’t quite sure what to expect because, as is usual, I picked the one day out of the entire week when the weather turned decidedly wet.Ī heavy mist hung in the air and the skies were grey and foreboding – not exactly an inviting scene when you’ve come to an island to explore its beaches. Not quite the eyeball-popping landscape you’ll find on Skye, but wild, open, and atmospheric all the same. That’s pretty impressive when you consider that deer on Jura outnumber humans 25 to 1!īut it’s not just the animals that make Jura worthy of a visit as the scenery is absolutely drop-dead gorgeous. Not that Craighouse is a large village (it’s actually tiny) but there’s a distillery sited in the centre of it along with a hotel that overlooks a very picturesque beach, so it’s certainly worth visiting if you ever decide to take the ferry from Port Askaig to explore the remarkable landscape.Īlthough Jura is quite small at 142 square miles it’s absolutely full of wildlife and a visit will almost certainly guarantee sightings of herds of red deer, whose numbers currently hover around the 5000 mark. |